Why do I have schizophrenia during my menopausal syndrome?

Condition analysis: 

In most cases, Schizophrenia first manifests in young adulthood, with the rate of new cases declining in both male and female individuals after this time. A second peak in the incidence of schizophrenia is noted among women aged 45-50 years; this second peak is not observed in men.

Some researchers have observed a worsening of the course of schizophrenia in women during the menopausal transition. These observations suggest that estrogen may play a modulatory role in the pathophysiology of schizophrenia. 

Instructions:

Improvement of mood and quality of life: In women with mild mood-disorder symptoms that do not meet the criteria for depression, hormone replacement therapy may be considered. The effects of estrogen treatment have been studied in perimenopausal women without depression to see if it has a positive effect on mood or quality of life. Results from small studies have suggested a small positive impact on mood. However, most data suggest that, among healthy women without depression, estrogen has no favorable effect on quality of life or mood.