Polyuria exists when excessive urine output occurs, beyond that which is necessary to control the internal composition of the body's fluids. There are a variety of reasons why this can occur. They include diseases within the kidney as well as diseases in the pituitary-hypothalamus, that portion of the brain which is responsible for the control of urine output. In addition, excessive water intake as well as a variety of metabolic substances can lead to increased urine output. Polyuria can lead to disruptions in the delicate balance of electrolytes in the body. Polyuria has been associated with renal failure.

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