Approximately 90% of condyloma acuminata are related to HPV types 6 and 11. These 2 types are the least likely to have a neoplastic potential. Risk for neoplastic conversion has been determined to be moderate or high, with many other isolated types. The picture is complicated by proven coexistence of many of these types in the same patient, the lack of adequate information on the oncogenic potential of many other types, and ongoing identification of additional HPV-related clinical pathology.

For example, bowenoid papulosis, seborrheic keratoses, and Buschke-L?wenstein tumors have been linked to HPV infections though they were previously a part of the differential diagnosis of condyloma acuminata. Bowenoid papulosis consists of rough papular eruptions attributed to HPV and is considered to be a carcinoma in situ. The eruptions can be red, brown, or flesh colored. They may regress or become invasive. Seborrheic keratoses previously were considered a benign skin manifestation. HPV has been linked to rough plaques indicative of this disease. It has both an infectious and an oncogenic potential. Finally, Buschke-L?wenstein tumor is a fungating, locally invasive, low-grade cancer attributed to HPV.

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