Under pathological conditions, meridians become the routes to transmit pathogenic factors. Pathological changes of the viscera and meridians can be revealed by abnormal reactions along the routes along which the meridians run. So meridians are also helpful for diagnosing diseases, which is recorded in the chapter of Back-Shu acupoints in Lingshu (Spiritual Pivot). Currently, diagnosis is made by examining whether there appear tenderness, subcutaneous nodules, prominence and depression along the meridian routes or by pressing Shu-Stream, Front-Mu, Yuan-Source, Luo-Connecting and Xi-Cleft acupoints.
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