The historical documents have focused mainly on the synergistic, positive effects of pair-point. Few have mentioned that the combination of two acupuncture points can produce conflicting effects. Modem research has found that some combinations may not produce the desired effects. For example, Xu fangming observed that with regard to facilitating digestive function, Neiguan (PC6) in combination with Pishu (BL20) or Zusanli (ST36) paired with Neiguan (PC6) have synergistic effects yet combining all three, Neiguan (PC6), Pishu (BL20), and Zusanli (ST36) can lead to conflicting effects. However. as Li xuehui has observed in measurement the rate of oxidation in mice, the combination of Neiguan (PC6) and Pishu (BL20) and the combination of Zusanli (ST36), Neiguan (PC6) and Pishu (BL20) result in conflicting treatment effects. When used on their own, each of the three points has similar and significant treatment effects. Nevertheless in combination there is no apparent increase or decrease in treatment efficacy.