Causes of Ampullary Cancer
Following are some important causes of Ampullary Cancer. In presence of following factors , risk of Ampullary Cancer increases to many folds, they include:

Genetic factors appear to play a major role in the development of ampullary cancer. Patients with familial adenomatous polyposis have an increased risk of suffering from ampullary cancer. The incidence is higher in patients who have inflammatory bowel disease.

Genetic alterations like K-ras mutations, mutations in tumor suppressor genes such as p53 DPC4/SMAD4, transforming growth factor-?-receptor-II (growth factor receptor TGF-?R-II) are associated with ampullary cancer.

At the chromosomal level, loss of alleles of chromosome 17p and 18q are associated with ampullary cancer (55% and 36%).

Other factors like cigarette smoking and diabetes mellitus may be associated with ampullary cancer.