Most individuals with empty sella syndrome do not have any symptoms and do not require treatment. When symptoms do occur, treatment is directed toward the specific symptoms that are apparent in each individual. If the pituitary is affected, then replacement therapy for specific hormones should be administered as needed. Surgery may be necessary when cerebrospinal fluid leaks from the nose (CSF rhinnorhea).

Prognosis
Empty sella syndrome (ESS) is not a life-threatening illness. In most cases, especially in people with primary ESS, there are no symptoms and it does not affect life expectancy.  ESS is often found incidentally on an X-ray when people are being evaluated for other reasons. Therefore, many people with ESS are probably never diagnosed. Some researchers have estimated that less than 1% of affected people ever develop symptoms of the condition. People with normal pituitary function usually do not need any treatment. Some people (particularly those with secondary ESS) may need hormone replacement therapy. In a few cases, surgery may be needed to repair the sella turcica.  If a person has ESS that is associated with an underlying condition, the long-term outlook (prognosis) may depend on that of the specific condition present.