The drug of choice for the treatment of hookworm disease is mebendazole which is effective against both species, and in addition, will remove the intestinal worm Ascaris also, if present.  The drug is very efficient, requiring only a single dose and is inexpensive – the "perfect drug".  However, treatment requires more than giving the anthelmintic, the patient should also receive dietary supplements to improve their general level of health, in particular iron supplementation is very important.

Topical treatment with thiabendazole ointment is very effective in controlling dermal larval migrans.