Treatment for lymphocytic colitis varies, depending on the symptoms and severity of the disease. The disease has been known to resolve on its own, but most people have recurrent symptoms.
 
Lifestyle changes aimed at improving diarrhea are usually tried first. Recommended changes include:
__Reducing the amount of fat in the diet
__Eliminating foods that contain caffeine or lactose
__Not using NSAIDs.
    
If lifestyle changes alone are not enough, medications are often used to control symptoms.
 
Antidiarrheal medications (such as bismuth subsalicylate) and bulking agents (such as fiber supplements) can help reduce diarrhea. Anti-inflammatory medications, such as mesalamine, sulfasalazine, and steroids (including budesonide), reduce inflammation. Immunosuppressive agents, which reduce the autoimmune response, are rarely needed.
 
For extreme cases of lymphocytic colitis, bypass of the colon or surgery to remove all or part of the colon has been done on occasion. However, these surgeries are rarely recommended.