There is no cure for LEMS. Treatment may vary depending on the individual's age, general health, and whether there is an associated cancer or autoimmune disorder. If cancer or an underlying autoimmune disorder is present, treatment should focus on these conditions first. They may result in symptom relief.

Medications and therapies that may be used to treat Lambert-Eaton myasthenic syndrome include: 3,4-diaminopyridine (enhances acetylcholine release), anticholinesterase agents (e.g., Pyridostigmine), plasma exchange (where blood plasma is removed and replaced with fluid, protein, or donated plasma), intravenous immunoglobulins (IVIG), and medications that suppress the immune system (e.g., prednisone, azathioprine).