Usually, primary stabbing headache occurs a few times a day at most. In rare cases, however, they occur more frequently, requiring treatment. The major problem with treatment is that the pain is so brief that it is gone before the person can even take medication. In those rare cases where it is happening so frequently that it does need treatment, preventive treatment-a medicine that you take every day whether you have pain or not to prevent the pain from occurring-is recommended. Melatonin or indomethacin may be helpful for prevention of primary stabbing headache. Those who do need to use indomethacin for prevention should remember that it is a non-steroidal anti-inflammatory drug (NSAID) and has potential side effects typically associated with NSAIDs. Some potential side effects include heartburn, nausea, gastroesophageal reflux, bleeding problems and stomach ulcers.