Symptoms of Analgesic Nephropathy
Patients present with kidney injury and usually non-nephrotic proteinuria with a bland urinary sediment or sterile pyuria.

Hypertension, anemia, and impaired urinary concentration are common once renal insufficiency develops.

Flank pain and hematuria and passage of a renal papilla (causing upper urinary tract obstruction) are signs of papillary necrosis that occur late in the course of disease.

Chronic complaints of musculoskeletal pain, headache, malaise, and dyspepsia may be related to long-term analgesic use rather than analgesic nephropathy.