Causes of Bladder Exstrophy
Bladder exstrophy (BE) usually occurs early in a fetus’ development around 4–5 weeks after conception, but researchers don’t know exactly why this happens.

It has been suggested genetics may play a role. Some researchers believe a child whose parent has BE would have an increased risk for developing the condition. Further, having a sibling with the condition increases risk, but the risk is relatively small. Unfortunately, theories on genetic and family history risk factors are mostly speculative and/or have limited research and evidence to back them up.

Research reported in the medical journal Pediatric Urology suggests maternal age, race (BE is more common in whites than in other races), and birth order (most cases of BE appear to be in firstborns) are risk factors for BE. However, that report did not provide any evidence of inherited mutations that could play a role in the development of the condition.