Shortness of breath (SOB) is a common problem that we see in the emergency department. While most of the causes are respiratory or cardiac, other systems may be the cause, so it is important to have an open mind when considering the differential diagnosis of the patient with SOB. --Acute Pulmonary Oedema --Endocrine --Haematological --Psychiatric --Toxicology --Massive Ascites --Neurological disease --Differential Diagnosis --Asthma and COPD --Pneumonia --Pneumothorax --Pulmonary Embolism --Trauma --Acute Coronary Syndrome