The main cause of hypoglycemic coma is sharp reduction in blood glucose levels. There are a number of ways this can occur. Inadequate diet with skipping meals might result in dropping blood sugar levels, and people with diabetes are particularly vulnerable to this. Excessive alcohol intake is another precursor for this form of coma. An additional cause is injection of too much insulin, which can quickly drop blood sugar levels.

Causes and Risk Factors of Hypoglycemic Coma include:
In Diabetes Type 1
1. Insulin overdose
2. Inadequate food intake, too long interval between injection and meal
3. Intense and prolonged exercise
4. Suppression of  certain medications
5. Alcohol abuse.

In Diabetes Type 2
1. Sulfonamides overdose, especially with generation 2 sulfonamides and insulin overdose
2. Additional drugs (coumarin, phenylbutazone, sulfonamides, b-blockers)
3. Travelling and diminished food intake.