Liver disease mainly manifests in the liver proper and its abnormal changes in dispersing as well as in storing blood. The clinical manifestations are depression, or irritability, susceptibility to rage, distending pain in chest, hypochondrium and lower abdomen, dizziness, tremor of limbs, spasm of hands and feet, bitter taste in the mouth and jaundice. Besides, eye disorders and irregular menstruation are usually believed to be caused by disorder of the liver because the liver opens into the eyes and the liver is the essential organ in woman.
 
The liver disease is either asthenia or sthenia. The asthenia syndrome of liver is often caused by insufficiency of liver yin and liver blood due to malnutrition after prolonged duration of disease, or involvement in the disorder of other organs, or bleeding; sthenia syndrome of liver is usually caused by liver depression and qi stagnation, exuberance of liver fire, hyperactivity of liver yang, damp heat in the liver and gallbladder and retention of cold in the liver vessel due to emotional impairment, transformation of fire from qi stagnation, upward adverse flow of qi and fire, or internal invasion of pathogenic cold, fire and damp heat. If pathogenic fire scorches liver yin and yin asthenia fails to control yang, yang will become hyperactive and transform into wind, therefore leading to endogenous of liver wind.