There is no easily definable cause of intraventricular hemorrhage. The condition occurs because blood vessels are not fully developed or strong enough to support the blood flow (which is why this is rarely found in more developed babies).

While intraventricular hemorrhage could be caused by a head injury or pressure from delivery, it can also occur without much warning or reason.

Many factors can contribute to the likelihood of this condition. Premature babies are most at risk, especially those born ten weeks early or earlier. The more premature a baby is, the more at risk he or she is for this and other health complications.

Preemies born with respiratory problems (like RDS) or other complications because of prematurity are also at higher risk. Babies who experience other blood-related problems, infections, and/or shaken baby syndrome have an increased risk of intraventricular hemorrhage.