People who have Acute Neutropenia can develop symptoms over the course of a few days or even hours. Chronic Neutropenia sufferers can develop the disease gradually, but are affected for months, and even years. Chronic Neutropenia will often exhibit no symptoms until an infection sets in. These infections usually manifest themselves in the mouth, throat, sinuses, lungs, and skin. They show up in the form of fever, mouth ulcers, anal sores, ear and gum infections, tonsilitis, sore throats, skin abscesses, and even periodontal disease. In some cases, life-threatening infections or sepsis can set in, requiring hospitalization and intravenous administration of antibiotics.

Other symptoms of Neutropenia include diarrhea, shortness of breath, chills, a burning sensation when urinating, and excessive swelling, pain and redness in wounds.