TCM diagnosis based on syndrome differentiation:
1. Deficiency of Spleen and Kidney
Symptoms: pale complexion, fatigue, sore backs and knees, loose stool, frequent micturition at night, poor appetite, aversion to cold, whitish coating, deep pulse.

2. Deficiency of Qi and Blood
Symptoms: pale complexion, shortness of breath, dizziness, palpitation, low spirits, dark urine, whitish coating, thin pulse.

3. Retention of Damp-heat in the Interior
Symptoms: Yellow skin and sclera, dark urine, pale complexion, fatigue, nausea, fever, yellow and greasy coating, slippery pulse.

Diagnosis in western medicine
A 3-stage investigation is performed for making its diagnosis. The first test is comprised of a flow cytometry analysis, which helps to determine if any blood cell lacks the GPI-anchored proteins. The second test is carried out to analyze markers in blood for establishing the presence of hemolysis. Once these two tests have been completed, the diagnostician performs bone marrow analysis for detecting signs of another blood disorder such as aplastic anemia, myelodysplastic syndrome and myelofibrosis.

The diagnostic tests used for this condition include:
Ham test or acid hemolysin test
Sucrose hemolysis test (Sugar-Water Hemolysis Test)
Urinalysis or urine test
Complete blood count (CBC)
Coombes’ test