Langerhans cell histiocytosis (LCH) is a neoplastic proliferation of Langerhans cells can express CD1a, S-100 protein, visible Birbeck granules by ultrastructural examination. Langerhans cell histiocytosis is referred to the past "histiocytosis X" and the rare "Langerhans cell granulomatous disease." Clinical subtypes means "Letterer-Siwe disease" and solid "eosinophilic granuloma." The incidence is about 5 / million, the majority of cases occur in children, is addicted to males (male to female ratio of 3.7:1). It is more common in the Nordic whites, and blacks normal or rare. Disseminated Langerhans cell histiocytosis and acute lymphoblastic leukemia show some correlation. With the initial infection, sexual contact and lack of solvent exposure vaccination in infancy have a certain relationship. Langerhans cell histiocytosis is also associated with malignant lymphoma - non-Hodgkin's or Hodgkin's lymphoma. In adults, the lungs of Langerhans cell histiocytosis has a lot to do with smoking, which may be representative of an independent, may be reactive type of disease.
Complications of
Langerhans Cell Histiocytosis 1.
Diabetes insipidus
2. Stunted growth/failure to achieve sexual maturity
3. Defects of bone/skull defects/facial asymmetry
4. Loss of spinal height
5. Loss of teeth
6. Bulging of the eyes
7. Hearing loss
8. Scarring of the skin
9. Scarring of the liver
10. Scarring of the lung
11. Secondary cancers
12. Neurologic/cerebellar problems