The types and severity of symptoms of Reiter's syndrome vary between individuals. Symptoms of Reiter's syndrome are due to inflammation that can affect the urinary tract, genitals, reproductive system, eyes, skin, mucus membranes, as well as the muscles and joints. However, not all people will have all symptoms, and all symptoms may not occur together at the same time. Symptoms generally develop two to four weeks after a Chlamydia infection or food poisoning. Symptoms can come and go, but generally go away spontaneously within about a year.

Symptoms of Reiter's syndrome can affect the urinary system and reproductive system. Symptoms can include burning or pain with urination, urethral discharge, and frequent urination. Men with Reiter's syndrome can develop prostatitis. Women can develop salpingitis, vulvovaginits, cervicitis, or salpingitis. Symptoms that affect the eyes include red, burning eyes with discharge due to the development of conjunctivitis. The eyes can also be sensitive to light. Symptoms that affect the skin include skin rashes and skin lesions, especially on the palms and soles. Lesions can also develop on the penis and in the mouth. Symptoms that affect the muscles and joints include Achilles tendon pain, low back pain, heel pain, and joint pain due to the develoment of arthritis. Joint pain occurs most often in the hips, knees and ankles. Complications include the development of chronic arthritis.