Chronic granulomatous disease (CGD) is an immunodefiency disease, that is, a disorder in which the immune system does not function properly. It affects the white blood cells of the innate immune system, the branch of the immune system that responds in a nonspecific way to invading microorganisms. There are many forms of this CGD, all caused by various genetic mutations. The immunodeficiency leads to infections and inflammation in various parts of the body. When CGD causes chronic inflammation of the prostate, it is called chronic granulomatous prostatitis.