Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth disease (CMT) or hereditary motor and sensory neuropathy (HMSN) is a common neurological disorder that causes muscle weakness and nerve damage in the legs and arms. CMT is caused by a mutation in genes that create proteins for the nervous system.

These mutations affect peripheral nerve axons, or parts of nerve cells in which convey electrical signals, and they affect myelin sheaths, which insulates nerve cells. Because CMT is caused by genetic mutations, doctors will look at a patient’s family history along with a medical history and examination to diagnose the disease.