Cimicifuga Racemosa And Guaiacum
Cimicifuga is the best homeopathic medicine for ankylosing spondylitis when there is  marked stiffness in neck area .  For Cimicifuga to be used the patient may exhibit the following symptoms-  is excessive stiffness in neck with severe pain. Neck muscles feel retracted. Neck stiffness is worsened in cold air. Lumbosacral pains extending down hips and thighs are also present. Homeopathic medicine Guaiacum is equally effective for relieving neck stiffness . Guaiacum is indicated when there are contractive pain between scapulae . Stiffness from neck may also extends to shoulders. Shoulder blades are also painful.

Kalmia
Kalmia is an appropriate choice of homeopathic medicine in ankylosing spondylitis cases where pain & stiffness are marked in lower back and neck area.  For Kalmia to be used the following symptoms may be present –  There is pain, lameness, stiffness in lumbosacral area. The pains are accompanied with heat & burning in affected area.  Numbness and pricking sensation may appear at painful site. In addition to this neck pain and stiffness are marked. The neck region is sore and tender to touch. Pain is attended with excessive stiffness in neck. The pain from neck often radiates down the arm or in the scapula. The pain usually appears in paroxysms. The pains are worse in the early part of night.

Aesculus
Aesculus is one of the best homeopathic remedy to begin treatment of ankylosing spondylitis. The main indicating feature for its use is marked pain in lumbosacral area of the back and hips with extreme stiffness. For Aesculus to be used the following symptoms may be present –  Pain from the back may radiates to thighs. Pain may be of aching, sore, tearing nature or it is can be  severe that it may give sensation of a broken back. Rising from seat, walking and stooping are all difficult and painful. The patient has to make repeated efforts to rise from seat. Severe pains and stiffness in lumbosacral region make it impossible to walk. Pain in sacroiliac region and back appears and person feels as if legs & back would give out when walking.  Back is extremely rigid, stiff, weak and painful.

Rhus Tox
Rhus Tox occupies a high position in homeopathy to treat various kinds of pain. In ankylosing spondylitis it is applicable when pain and stiffness in back and hips is worse when person is at rest.  For rhus tox to be used following symptoms may be present – Pains are aggravated after a period of inactivity. Walking helps to relieve the backache and hip pain. There is marked stiffness, lameness and pain in lumbosacral area of  back and hips. The pain goes down from back and hips to thighs. Sitting aggravates the pains. Hard pressure and lying on something hard seems helpful in providing relief in the pains. Rest worsens the pain and motion relieves.