Treatment for decreasing bone marrow size due to myelofibrosis

Condition analysis:
Myelofibrosis is a chronic myeloproliferative disorder. It is characterised by replacement of bone marrow by fibrosis. Normally, bone marrow contains hematopoietic cells which produce red blood cells (RBC), white blood cells (WBC) and platelets.

In myelofibrosis is a condition where these hematopoetic cells are replaced leading to reduced production of cells of all these three lineage.

Decrease in blood components requires regular blood transfusion.

Bone marrow transplantation is the permanent cure but the success rate of bone marrow transplant varies from centre to centre and from patient to patient.

Bone marrow transplantation requires a donor with HLA matching.

HLA matching is done among blood relations. Siblings have the highest chance of matching.

This is a sophisticated procedure done at tertiary health care level.

Some of the centres performing bone marrow transplant are: Christian Medical College Vellore & Ludhiana, Tata Medical centre Kolkatta, Apollo hospitals, AIIMS etc. You can visit an oncology centre nearest to your place.

Thank you and take care

Instructions:
Although the cause of myelofibrosis often isn't known, certain factors are known to increase your risk:
-- Age. Myelofibrosis can affect anyone, but it's most often diagnosed in people in their 50s and 60s.
-- Another blood cell disorder. A small portion of people with myelofibrosis develop the condition as a complication of essential thrombocythemia or polycythemia vera.
-- Exposure to certain chemicals. Myelofibrosis has been linked to exposure to industrial chemicals such as toluene and benzene.
-- Exposure to radiation.