Fever, influenza virus treated with TCM bupleurum

What is bupleurum(Chai Hu)? Also known as radix bupleuri, it refers to the dried root of Bupleurum chinense DC. or Bupleurum scorzonerifolium Willd., which are perennial umbelliferous plants. Else, it is also being called thorowax root. They are usually collected in spring and winter for medicinal purpose, stems, leaves, and dirt removed, and then dried in the sun.

What is bupleurum used for?
It is one of the most commonly used herbs in Chinese herbal remedies. Now the modern medicine research also indicates that this is a versatile herb.

Modern pharmacological actions
Bupleurum contains A, B, C, D types of saikosapoins, sterol, essential oils like bupleurumol and eugenol, fatty acids like oleic acid, linoleic acid, palmitic acid, and stearic acid, and polysaccharide, etc. And it has the typical actions as follows:

1. Aritipyretic effect. Early studies found that large dose of bupleurum decoction, 5 grams/kg, could bring down a fever on rabbits that were induced fever artificially;

2. Sedation and analgesia. Taking saikosaponins orally could calm down mice and prolong the sleep induced by benzodiazepines. In addition, sailkosaponins could ease pain while relieving a cough;

3. Anti-inflammation. Saikosaponin at the dose of 600mg/kg could dramatically lower paw swelling induced by dextran and serotonin (5-HT) in rats;

4. Antiviral effect. Reportedly Injection Bupleuri could inhibit influenza virus effectively;

5. Effects on the liver. Fed on bupleurum, the rats, with acute liver dysfunction induced by moldy rice, have a much lower level of ALT and AST.