Gilbert's syndrome is due to a genetic mutation that causes only 30% of the enzyme UGT1A1 to be produced. This is the only enzyme that detoxifies bilirubin, a toxic product of the natural breakdown of red blood cells. This enzymatic shortage leads to an excess of bilirubin (and other toxins) in the blood serum. Most people with Gilbert's Syndrome also have linked mutations in two other enzymes - UGT1A6 and UGT1A7, causing similar enzyme shortages which leads to their related toxins circulating in the body for longer periods as well.
Symptoms of Gilbert's Syndrome:
1. Frequently Reported: fatigue, tiredness, brain fog, headaches, poor memory, dizziness, depression, irritability, anxiety, nausea, loss of appetite, irritable bowel syndrome (IBS), stomach pain & cramping, liver/gallbladder pain, abdominal pain, tremors, itchiness, jaundice
2. Commonly Reported: insomnia, difficulty concentrating, panic attacks, hypoglycemic reaction to foods, intolerance to carbs, food intolerances, alcohol intolerance, loose stools / diarrhea, abdominal bloating or swelling, breathlessness or labored breathing, heart palpitations, aching muscles / body ache, joint pain, numbness & tingling, weakness, chemical sensitivity, weight loss, lump in the throat, feeling constantly sick.
3. Sometimes Reported: difficulty finding the right words, feeling drunk, vomiting, intolerance to fatty foods, strong hangovers, acid reflux, excessive thirst, chest pain, muscle twitches, cold hands and feet, environmental allergies, swollen lymph nodes, toxic feeling, bitter or metallic taste in the mouth, eye pain.
4. Occasionally Reported: waking panic attack, mood swings, feeling antisocial, intolerance to drugs, constipation, pale stools, indigestion, back pain, dry skin, feeling cold, low body temperature, pale skin, low weight, night sweats, excessive sweating, poor immune system, sore or dry throat, light sensitivity, bloodshot eyes.