This disease occurred in the 30-50 years of age. No significant gender differences. At present, most scholars advocate the use of lever classification, namely, 1. pemphigus vulgaris, about 2 / 3 2. Leaves pemphigus. pemphigus erythematosus, accounting for about 15%. Proliferation of pemphigus, accounting for about 3%. (A) pemphigus vulgaris; the skin to sudden large soy beans large blisters, sometimes up to a large walnut, thin-walled blisters and more relaxed, blister fluid began to clear, cloudy later with blood blisters rupture to form blister fluid crusting, erosion, often specific stench. The external force, easy to peel skin, or gently oppression complete bulla, blister fluid from the pressure points within the bullae spread to the surrounding, as nikolsky positive sign. Its pathogenesis is due to epidermal cell layer of the spine spine release, and the lack of epidermal cell cohesion. Generally only mild itching, pigmentation left after treatment, no scars.

About 80 % of the patients involved oral, genital, and conjunctiva, oral mucosa erosion occurred stubborn wide range of easily bleeding, burning pain was often early symptoms of the disease. herpes can occur in various parts, back, axillary and groin are more likely to occur . Generalized body blisters, there a wide range of erosion surface, complicated by infection, fever, general weakness and other symptoms. (B) the proliferation of pemphigus: pemphigus vulgaris is shaped, skin lesions occur in the head, face, armpits, chest and back, etc ..