The causes of this disease include congenital insufficiency, diet and trauma, etc. Viral infection or drug administration affecting the fetus in pregnancy as well as intrauterine suffocation of the fetus during delivery affects the normal development of the fetus; parental pychoneurosis causes weak physique of the infantile patient and imbalance of yin and yang; malnutrition, or imbalanced diet, or excessive ingestion of uncooked and cold food impairing the spleen and stomach leads to deficiency of qi and blood, loss of nourishment of the heart and mind; excessive intake of fat and sweet food causes dampness, heat and phlegm, blocking functional activities of qi and disturbing the mind.

Birth injury and other traumas result in infantile stagnation of qi and blood, obstructive meridians as well as perturbation due to loss of nourishment of the heart and liver; after recovery from other primary diseases, deficiency of qi and blood, or disorder of qi and blood in circulation still exists in the body and makes the heart and mind lose nourishment, giving rise to failure of the heart to store mind. All the above factors may give rise to infantile hyperactive syndrome.