Causes of Hepatosplenomegaly Hepatosplenomegaly is a medical condition in which both the liver and the spleen become enlarged. There are different medical conditions that can lead to the simultaneous appearance of hepatomegaly and splenomegaly, as you will have the opportunity to discover below. It is important to understand that this condition can lead to a serious or life-threatening symptoms, if proper medical treatment is not administered. The sooner the patient starts the treatment, the more reduced are the chances of developing such symptoms.
The liver is involved in a multitude of bodily functions, and is affected by a variety of conditions, many of which result in hepatomegaly. Common causes include: Hereditary fructose intoleranceGlycogen storage diseasePrimary biliary cirrhosisSarcoidosisSclerosing cholangitisHemolytic-uremic syndrome (HUS)Reye's syndromeAlcoholHepatitis AHepatitis BCongestive heart failureInfectious mononucleosisLeukemiaTumour metastasesNeuroblastomaHepatocellular carcinomaNiemann-Pick disease