Conditions that may lead to Diabetic nephropathy in modern medicine:
1. Hypertension
It is most commonly seen cause of Diabetic Nephropathy that almost all the patients with Diabetic Nephropathy suffer from hypertension. Those with type 1 Diabetic Nephropathy suffer from hypertension and slight proteinuria simultaneously while type 2 suffer from hypertension in advance before Diabetic Nephropathy. In a word, the control of blood pressure is closely related to the progress of Diabetic Nephropathy.

2. Renal hemodynamic abnormalities
One of the significant causes of Diabetic Nephropathy that renal hemodynamic abnormalities can be detected in early period, which behaves as increased renal blood flow and GFR.

3. Genetic factors
The suffering percentage of male is higher than female while African and Mexican are more susceptible compared with the white race under the same living environment according to American research. Besides, certain families are easy to suffer from Diabetic Nephropathy, which points out the existence of genetic factors that slight proteinuria is diagnosed from 40%~50% patients of type 1 diabetes while 20%~30% patients with diabetes turn out to be Diabetic Nephropathy.

4. Metabolic disorder attributes to hyperglycemia
Hemodynamic changes or metabolic disorders are main pathological injuries of renal damage caused by hyperglycemia while the former mainly includes partial insufficiency of carbohydrate metabolism of renal tissue and activation of polyol pathway, etc.