Practitioners use moxa to warm regions and acupuncture points with the intention of stimulating circulation through the points and inducing a smoother flow of blood and qi. Scientific research has shown that mugwort acts as an emmenagogue, meaning that it stimulates blood-flow in the pelvic area and uterus. It is claimed that moxibustion militates against cold and dampness in the body and can supposedly serve to turn breech babies.

Medical historians believe that moxibustion pre-dated acupuncture, and needling came to supplement moxa after the 2nd century BC. Different schools of acupuncture use moxa in varying degrees. For example a 5-element acupuncturist will use moxa directly on the skin, whilst a TCM-style practitioner will use rolls of moxa and hold them over the point treated.

Practitioners consider moxibustion to be especially effective in the treatment of chronic problems, "deficient conditions" (weakness), and gerontology. Bian Que (fl. circa 500 BC), one of the most famous semi-legendary doctors of Chinese antiquity and the first specialist in moxibustion, discussed the benefits of moxa over acupuncture in his classic work. He asserted that moxa could add new energy to the body and could treat both excess and deficient conditions. On the other hand, he advised against the use of acupuncture in an already deficient (weak) patient, on the grounds that needle manipulation would leak too much energy.

A huge classical work, Gaohuang (BL43), specializes solely in treatment indications for moxa on a single point. Note that Taoists use scarring moxibustion along with Chinese medical astrology for longevity. Practitioners may use acupuncture needles made of various materials in combination with moxa, depending on the direction of qi flow they wish to stimulate.