Jueyin diseases indicate the last stage of disease transformation of the six channels. This disease condition is complex with syndromes of extreme heat or extreme cold, or syndromes of alternate cold and heat.

Extreme cold syndromes
Cold extremities, absence of fever, aversion to cold, pale tongue, and an extremely thready, feeble pulse that can hardly be felt.
Syndromes of extreme cold result from yang xu (deficiency) and excessive yin.

Extreme heat syndromes
Coldness of extremities, irritability, feverish sensation, thirst, yellowish urine, yellowish tongue coating and slippery pulse.
Irritability, feverish sensation, thirst, yellowish urine, yellowish tongue coating and slippery pulse are signs of interior accumulation of heat.

This interior accumulation causes a failure of the yang qi to warm and nourish the body surface. The resulting cold extremities are considered "coldness due to extreme yang," or "coldness due to extreme heat." Syndromes of extreme cold are also known as "coldness due to extreme yin."

Coldness due to ascariasis syndromes
Cold limbs, xiao ke (general term for diseases with symptoms of frequent drinking, of water, urination and bowel movements), a feeling of qi striking upward, pain and feverish sensation of the heart, hunger without appetite, vomiting ascariasis after eating food and serious diarrhea.

This condition is caused by parasitosis accompanied with mixed heat and cold. The symptoms of xiao ke, a feeling of qi striking upward, and pain and feverish sensation of the heart are heat syndromes. Hunger without appetite, vomiting ascariasis after eating, and serious diarrhea are cold syndromes. The mixture of heat and cold and the disharmony of yin and yang causes coldness of the limbs. Ascariasis disturbs the upper part of the body, manifesting irritability, and vomiting ascarids after eating.