After produced in the convoluted seminiferous tubule of testicle, sperms firstly enter the epididymis, and then go into the seminal vesicule through spermaduct. seminal vesicle secretes seminal vesicle fluid to provide necessary substance for their living. If bacteria in the urethra get into the prostate, vesicula seminalis, spermaduct, epididymis and testicle through the ejaculatory duct, it probably causes inflammatory affection, result in prostatitis, vesiculitis, vasitis, Epididymitis, etc.

When bacteria reproduce in the genital tract, they secrete some kind of hazardous substance to sperms; bacteria reproduction also needs great amount of nutriment, hence, it decreases nutriment provided to sperms, destroys sperms living environment, kills sperms and results in necrospermia; numerous acid products are discharged while bacteria reproducing, which lower the PH value in genital tract, make sperms dead for acidosis; bacteria reproduction also consumes a great deal of oxygen and forms a oxygen-poor environment for sperms, finally causes necrospermia. To sum up, bacterial infection in genital system leads to necrospermia. Therefore, prostatitis and urethritis should be treated as early as possible, in order to avoid sperms death for bacterial reproduction.