1. Bones and muscles
People with Cushing's syndrome often have muscle weakness in their hips, shoulders, arms and legs.
Too much cortisol can also cause the bones to become weakened or brittle (osteoporosis). 

2. Depression and mood
Depression is common in people with Cushing's syndrome. It's also common to feel unusually tired all the time, which can contribute to feelings of depression.
People with Cushing's syndrome may also experience rapid mood swings or have emotional reactions

3. Weight gain and fat deposits
Weight gain is the most common symptom of Cushing's syndrome, particularly on the chest, stomach and face. 
People with Cushing's syndrome tend to have:
slim arms and legs compared with their chest and stomach
fat deposits on the back of the neck and shoulders 
a red, puffy, rounded face
Children who develop Cushing's syndrome tend to be obese and have slow growth rates.

4. Skin changes
Symptoms that affect the skin include:
thin skin that bruises easily 
spots on the face, chest or shoulders
darkened skin on the neck
swollen ankles caused by a build-up of fluid 
excessive sweating 
bruises, cuts, scratches and insect bites can take a long time to heal
reddish-purple stretch marks on the thighs, stomach, buttocks, arms, legs or breasts