Jueyin syndrome appears in the advanced stage of six meridians disorders due to cold-attack, marked by complex changes and mixture of cold and heat in pathogenesis. Upper-heat and lower-cold syndrome is taken as an example to show the characteristics of this syndrome. Jueyin syndrome is usually evolved from the disease lingering in the other meridians.
 
Clinical manifestations:
Thirst, qi rushing up into the heart, pain and feverish sensation in the heart, hunger without appetite, postcibal vomiting of ascaris, cold extremities and diarrhea.
 
Analysis of the symptoms:
Jueyin meridian pertains to the liver and distributes beside the stomach and through the diaphragm. So jueyin disease is marked by dysfunction of the liver and stomach. Complex of heat and cold is due to the fact that jueyin disorder affects dispersion and conveyance which leads to disorder of qi and imbalance between yin and yang; thirst, qi rushing up into the heart, pain and feverish sensation in the heart, hunger without appetite and postcibal vomiting are caused by invasion of adverse flowing liver qi into the stomach as well as heat in the stomach and adverse flow of qi; diarrhea is due to spleen asthenia and cold in the intestines; postcibal?vomiting of ascaris is due to upper-heat and lower-cold which drives ascaris to move upward with the rise of gastric qi.
 
The theory of six-meridians syndrome differentiation holds that the relation between pathogenic factors and viscera, meridians, qi and blood is characterized by transmission, combination of syndromes, complication and direct attack. The change of one meridian disorder into another meridian disorder is called meridian transmission; simultaneous of syndromes involving two or three yang meridians is called combination of syndromes; onset of another meridian disorder before one meridian disorder is relieved is called complication; if pathogenic factors at the primary stage of exogenous febrile disease do not transmit from the yang meridians but directly attack three yin meridians, it is called direct attack.