Chronic renal failure is the progressive and gradual loss of the ability of kidney to perform its functions normally. This condition occurs when there is a loss of nephrons of the kidney. Kidney completely depends of nephrons because it is the basic functioning unit of kidney. There are near about one million nephrons present in each kidney. As we know that, the main function of the kidney is to clean the waste products formed in the body and various toxics from the blood and concentrate the urine.

So if a person suffered from chronic renal failure then kidney is no longer be able to perform these tasks. When the function of renal fall below thirty milliliters per minute, which is about 30 % of the normal value. This can be check by measuring the renal function and it is measured as the glomerular filtration rate. When this rate shows kidney functioning below 30 milliliters per minute, different signs of urea start coming in view all that shows that person is suffering from this disease. Symptoms and signs of Chronic Renal Failure include as follows:

1. People with chronic renal failure need to urinate frequently, especially at night
2. Most people suffer from swelling of the legs and puffiness around the eyes
3. Blood pressure is unstable, most people have high blood pressure.
4. People with chronic renal failure low vital energy
5. loss of appetite, nausea and vomiting
6. Itching, easy bruising, and pale skin
7. Shortness of breath from fluid accumulation in the lungs
8. Headaches, numbness in the feet or hands, disturbed sleep, altered mental status
9. Chest pain due to pericarditis
10. Bleeding (due to poor blood clotting)
11. Bone pain and fractures
12. Decreased sexual interest and erectile dysfunction